The DivA-BE preprint is out!

Congratulations to Carley and all the authors on the bioRxiv preprint! The work characterizes the editing activity for a several diversifying base editors that produce C-to-N mutations. The study also establishes a more efficacious Diversifying AID fusion Base Editor, or DivA-BE for short. We recommend this editor for high-throughput studies identifying variants with an effect on cellular phenotype or engineering proteins in situ. This editor is 4-fold more efficient than the previous CRISPR-X editor, and diversifies its target site introducing mutations on both strands of DNA.

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First paper from the lab is out!