Publications





Schwartz CI*, Abell NS*, Li A, Aradhana, Tycko J, Truong A, Montgomery SB, and Hess GT. Towards optimizing diversifying base editors for high-throughput studies of single-nucleotide variants. bioRxiv.

*-These authors contributed equally

Tycko J, Van MV, Aradhana, DelRosso N, Ye H, Yao D, Valbuena R, Vaughan-Jackson A, Xu X, Ludwig C, Spees K, Liu K, Gu M, Khare V, Mukund AX, Suzuki PH, Arana S, Zhang C, Du PP, Ornstein TS, Kamber RA, Qi LS, Khalil AS, Bintu L, and Bassik MC. Development of compact transcriptional effectors using high-throughput measurements in diverse contexts. Nature Biotechnology. (2024).

Siepe DH, Henneberg LT, Wilson SC, Hess GT, Bassik MC, Zinn K and Garcia KC. Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform. eLife. (2022).

Tsedev U, Lin C-W, Hess GT, Sarkaria JN, Lam FC, and Belcher AM. Phage Particles of Controlled Length and Genome for In Vivo Targeted Glioblastoma Imaging and Therapeutic Delivery. ACS Nano. (2022).

Du PP*, Liu K*, Bassik MC, and Hess GT. Pathogenic or Benign? (News and Views). Nature Biotechnology. (2022).

*-These authors contributed equally

Aparicio-Prat E, Yan D, Mariotti M, Bassik M, Hess G, Fortin J-P, Weston A, Xi HS, and Stanton R.  Roadmap for the use of base editors to decipher drug mechanism of action. PloS one. (2021).

Wisnovsky S, Möckl L, Malaker SA, Pedram K, Hess GT, Riley NM, Gray MA, Smith BAH, Bassik MC, Moerner WE, and Bertozzi CR.  Genome-Wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. Proceedings of the Natl Acad of Sci USA. (2021).

Tycko J, DelRosso N, Hess GT, Aradhana, Banerjee A, Mukund A, Van MV, Ego BK, Yao D, Spees K, Suzuki P, Marinov GK, Kundaje A, Bassik MC, Bintu L.  High-throughput discovery and characterization of human transcriptional effectors. Cell. (2020).

Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Bohnert V, Maduke M, Bassik MC, and Li L.  LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. Molecular Cell. (2020).

Debets MF*, Tastan OY*, Wisnovsky SP, Malaker MA, Angelis N, Moeckl LKR, Choi J, Flynn H, Wagner LJS, Bineva-Todd G, Antononopoulos A, Cioce A, Browne WM, Li Z, Briggs DC, Douglas HL, Hess GT, Agbay AJ, Roustan C, Kjaer S, Haslam SM, Snijders AP, Bassik MC, Moerner WE, Li VSW, Bertozzi CR, and Schumann B.  Development of a precision metabolic labeling reagent to probe mucin-type O-glycosylation. Proceedings of the Natl Acad of Sci USA. (2020).

*-These authors contributed equally

Ferraro NM*, Strober BJ*, Einson J, Abell NS, Aguet F, Barbeira AN, Brandt M, Bucan M, Castel SE, Davis JR, Greenwald E, Hess GT, Hilliard AT, Kember RL, Kotis B, Park Y, Peloso G, Ramdas S, Scott AJ, Smail C, Tsang EK, Zekavat SM, Ziosi M, Aradhana, TOPMed Lipids Working Group, Ardlie KG, Assimes TL, Bassik MC, Brown CD, Correa A, Hall I, Im HK, Li X, Natarajan P, GTEx Consortium, Lappalainen T, Mohammadi P, Montgomery SB, and Battle A.  Transcriptomic signatures across human tissues identify functional rare genetic variation. Science. (2020).

*-These authors contributed equally

Morgens DW*, Chan C*, Kane AJ, Weir NR, Li A, Dubreuil MM, Tsui CK, Hess GT, Lavertu A, Han K, Polyakov N, Handy EL, Alabi P, Dombroski A, Yao D, Altman RB, Sello JK, Denic V, and Bassik MC.  Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins. eLife. (2019).

*-These authors contributed equally

Tycko J*, Wainberg M*, Marinov GK*, Ursu O, Hess GT, Ego BK, Aradhana, Li A, Truong A, Trevino AE, Spees K, Yao D, Kaplow IM, Greenside PG, Morgens DW, Phanstiel DH, Snyder MP, Bintu L, Greenleaf WJ, Kundaje A, and Bassik MC.  Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements. Nature Communications. (2019).

*-These authors contributed equally

Ritchie C*, Cordova AF*, Hess GT, Bassik MC, and Li L. SLC19A1 is an importer of the immunotransmitter cGAMP. Molecular Cell. (2019).

*-These authors contributed equally

Breslow DK*, Hoogendoorn S*, Morgens DW, Vu BK, Han K, Li A, Hess GT, Bassik MC, Chen JK, and Nachury MV.  A CRISPR-based screen for hedgehog signaling provides insights into ciliary function and ciliopathies.  Nature Genetics. (2018).

*-These authors contributed equally

Li X*, Kim Y*, Tsang EK*, Davis JR*, Damani FN, Chiang C, Hess GT, Zappala Z, Strober BJ, Scott AJ, Li A, Ganna A, Bassik MC, Merker JD, GTEx Consortium, Hall IM, Battle A, and Montgomery SB.  The impact of rare variation on gene expression across tissues.  Nature. (2017). 

*-These authors contributed equally

Tycko, J*, Hess GT*, Jeng EE*, Dubreuil M*, and Bassik MC.  The Expanding CRISPR toolbox (Poster).  Nature Methods. (2017).

*-These authors contributed equally

Hess GT*, Tycko J*, Yao D*, and Bassik MC.  Methods and applications of CRISPR-mediated base editing in eukaryotic genomes (Review).  Molecular Cell. (2017).

*-These authors contributed equally

Phanstiel DH*, van Bortle K*, Spacek D, Hess GT, Shamm MS, Machol I, Love MI, Aiden EL, Bassik MC, and Snyder MP.  Static and dynamic DNA loops form AP-1 bound activation hubs during macrophage development.  Molecular Cell. (2017). 

*-These authors contributed equally

Han K*, Jeng EE*, Hess GT, Morgens DW, Li A, and Bassik MC.  Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.  Nature Biotechnology. (2017).

*-These authors contributed equally

Morgens DW*, Wainberg M*, Boyle EA, Ursu O, Araya CL, Tsui K, Haney MS, Hess GT, Han K, Jeng EE, Li A, Snyder MP, Greenleaf WJ, Kundaje A, and Bassik MC.  Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens. Nature Communications. (2017).

*-These authors contributed equally

Pala M*, Zappala Z*, Marongiu M, Li X, Davis JR, Cusano R, Crobu F, Kukurba KR, Gloudemans MJ, Reinier F, Berutti R, Piras MG, Mulas A, Zoledziewska M, Marongiu M, Sorokin EP, Hess GT, Smith KS, Busonero F, Maschio A, Steri M, Sidore C, Sanna S, Fiorillo E, Bassik MC, Sawcer SJ, Battle A, Novembre J, Jones C, Angius A, Abecasis GR, Schlessinger D, Cucca F and Montgomery SB.  Population- and individual-specific regulatory variation in Sardinia. Nature Genetics. (2017).

*-These authors contributed equally

Hess GT, Fresard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, and Bassik, MC. Directed evolution using dCas9-targeted somatic hypermutation machinery. Nature Methods. (2016).

Arribere JA, Cenik ES, Jain N, Hess GT, Lee CH, Bassik MC, and Fire AZ.  Translation readthrough mitigation. Nature.  (2016).

Hess GT*, Guimaraes CP*, Spooner E, Ploegh HL, and Belcher AM.  Orthogonal labeling of M13 minor capsid proteins with DNA to self-assemble end-to-end multi-phage structures. ACS Synth Biol. (2013).

*-These authors contributed equally

Hess GT, Cragnolini JJ, Popp MW, Allen MA, Dougan SK, Spooner E, Ploegh HL, Belcher AM, and Guimaraes CP. M13 bacteriophage display framework that allows sortase-mediated modification of surface accessible phage proteins. Bioconj. Chem. (2012).

Hess GT, Humphries WH, Fay NC. and Payne CK. Cellular binding, motion, and internalization of synthetic gene delivery polymers. Biochim. Biophys. (2007).

Spasic A, Hess G, Becker KA, Hansen M, Bleil R, Mohanty U. Asymmetric charge neutralization of DNA.  Nucleic Acids: Curvature and Deformation ACS Symposium Series. (2004).

Liila-Fogarty SM, Boyum GE, Schwabe CL and Hess GT. A high-throughput screen for antiproliferative peptides in mammalian cells identifies key transcription factor families. ACS Synthetic Biology. (2024).